4-Chlorobenzenesulfonamide → HCID 22244564, compound

HRID 891150Notes

Reaction equation

[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][NH:15][C:16](=O)[O:17]C3C=CC=CC=3)=[CH:9][CH:8]=2)[N:5]=[C:4]([C:25]([F:28])([F:27])[F:26])[C:3]=1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.[Cl:35][C:36]1[CH:41]=[CH:40][C:39]([S:42]([NH2:45])(=[O:44])=[O:43])=[CH:38][CH:37]=1>>[NH2:1][C:2]1[N:6]([C:7]2[CH:8]=[CH:9][C:10]([CH2:13][CH2:14][NH:15][C:16]([NH:45][S:42]([C:39]3[CH:38]=[CH:37][C:36]([Cl:35])=[CH:41][CH:40]=3)(=[O:43])=[O:44])=[O:17])=[CH:11][CH:12]=2)[N:5]=[C:4]([C:25]([F:28])([F:27])[F:26])[C:3]=1[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

Reactant 2

HCID 668244-Chlorobenzenesulfonamide

HCID 22244660HCID 22244660, compound

Product 1

HCID 22244564HCID 22244564, compound

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 42 from phenyl 2-{4-[5-amino-4-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}ethylcarbamate (step 4 of Example 80) and 4-chlorobenzenesulfonamide: 1H-NMR (CDCl3) δ 7.85-7.80 (2H, m), 7.51-7.27 (11H, m), 6.08-6.03 (1H, m), 3.99 (2H, br.s), 3.50-3.44 (2H, m), 2.88-2.84 (2H, m).

Sources & evidence

ORD record: ord-eedb95bab3664fa88532a98bc837575d
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07001917B2

Reaction notes

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