4,4,4-Trifluoro-1-(pyridin-4-yl)butane-1,3-dione → 2-[4-[5-pyridin-4-yl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}ethanol

HRID 891151Notes

Reaction equation

HRID 891151 reaction equation
Cl.[NH:2]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][OH:12])=[CH:6][CH:5]=1)[NH2:3].[F:13][C:14]([F:27])([F:26])[C:15](=O)[CH2:16][C:17]([C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1)=O>>[N:22]1[CH:23]=[CH:24][C:19]([C:17]2[N:2]([C:4]3[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][OH:12])=[CH:8][CH:9]=3)[N:3]=[C:15]([C:14]([F:13])([F:26])[F:27])[CH:16]=2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 2382984,4,4-Trifluoro-1-(pyridin-4-yl)butane-1,3-dioneHCID 222447112-(4-Hydrazinophenyl)ethanol hydrochloride

Product 1

HCID 222445242-[4-[5-pyridin-4-yl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}ethanol

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 1 from 2-(4-hydrazinophenyl)ethanol hydrochloride and 4,4,4-trifluoro-1-pyridin-4-ylbutane-1,3-dione: MS (ESI) m/z 334 [M+H]+, 1H-NMR (CDCl3) δ 8.60-8.58 (2H, m), 7.28-7.24 (4H, m), 7.14-7.12 (2H, m), 6.88 (1H, s), 3.90-3.86 (2H, m), 2.92 (2H, t, J=6.6 Hz), 1.52 (1H, br.s).

Sources & evidence

ORD record
ord-a2d1349386984edeba86bae381f59344
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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