Sodium sulfate decahydrate → HCID 22244691, compound

Participants

Reaction Steps

To a stirred solution of lithium aluminum hydride (0.72 g, 15.1 mmol) and tetrahydrofuran (20 mL) was added slowly a solution of ethyl 6-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)nicotinate (step 1, 2.43 g, 7.56 mmol) and tetrahydrofuran (40 mL) at 0° C. After 2 h, sodium sulfate decahydrate and potassium fluoride were added slowly to the mixture at 0° C. The mixture was filtered through a bed of celite, and the filtrate was concentrated in vacuo. The residue was purified by silica-gel column chromatography eluting with hexane/ethyl acetate (1:1) to give 1.51 g (72%) of title compound as white solids: MS (ESI) m/z 280 [M+H]+, 1H-NMR (CDCl3) δ 8.42-8.41 (1H, m), 7.83-7.82 (2H, m), 7.47-7.28 (5H, m), 4.75 (2H, s), 2.58 (3H, s), 2.33 (3H, s), 2.30 (3H, s).

Provenance & Evidence