Hydrazine hydrate (1:1) → HCID 22244677, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of [6-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)pyridin-3-yl]acetonitrile (step 3, 633 mg, 2.20 mmol), Raney Ni (W2, 0.5 g), hydrazine monohydrate (1.1 mL, 22.0 mmol), and ethanol (20 mL) was stirred at 60° C. for 6 h. After cooling to room temperature, the mixture was filtered through a bed of celite. The filtrate was evaporated to afford 642 mg (quant.) of title compound: MS (ESI) m/z 293 [M+H]+.

Provenance & Evidence