N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide → N-(4-{1-[4-(2-Hydroxyethyl)phenyl]-3,5-dimethyl-1H-pyrazol-4-yl}phenyl)methanesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide	HCID 16217653	—
Reactant	2-[4-(4-Iodo-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol	HCID 22244559	—
Product	N-(4-{1-[4-(2-Hydroxyethyl)phenyl]-3,5-dimethyl-1H-pyrazol-4-yl}phenyl)methanesulfonamide	HCID 22244673	—

Reaction Steps

The title compound was prepared according to the procedure described in step 1 of Example 12 from 2-[4-(4-iodo-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol (step 2 of Example 11) and N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanesulfonamide: MS (EI) m/z 385 [M]+, 1H-NMR (CDCl3) δ 7.44-7.26 (8H, m), 3.92-3.90 (2H, br), 3.08 (3H, s), 2.94 (2H, t, J=6.6 Hz), 2.32 (3H, s), 2.29 (3H, s).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07001917B2
Source dataset	uspto-grants-2006_02
ORD ID	ord-af8a4dae2a8e414db5b623f4f2a5ff19
Source note	uspto-grants-2006_02