HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → isoquinoline-1-carboxylic acid {1-[(2-hydroxy-5-oxo-tetra-hydrofuran-3-ylcarbamoyl)methyl]-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl} amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | isoquinoline-1-carboxylic acid {1-[(2-ethoxy-5-oxo-tetra-hydrofuran-3-ylcarbamoyl)methyl]-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl} amide | HCID 86590750 | — |
| Solvent | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Product | isoquinoline-1-carboxylic acid {1-[(2-hydroxy-5-oxo-tetra-hydrofuran-3-ylcarbamoyl)methyl]-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl} amide | HCID 75025996 | — |
Reaction Steps
To a solution of isoquinoline-1-carboxylic acid {1-[(2-ethoxy-5-oxo-tetra-hydrofuran-3-ylcarbamoyl)methyl]-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl} amide, 6, from above in CH3CN/H2O is added trifluoroacetic acid. After stirring for 30 minutes the solution is concentrated in vacuo and the crude product purified by preparative reverse phase HPLC to afford the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07001899B2 |
| Source dataset | uspto-grants-2006_02 |
| ORD ID | ord-460d2057d4e04209a19a070ff7e863c1 |
| Source note | uspto-grants-2006_02 |