Trifluoroacetic acid → HCID 23598707, compound

Participants

Reaction Steps

A solution of isoquinoline-1-carboxylic acid {6-(benzenesulfonylamino-methyl)-1-[(2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl}-amide, 35, as prepared in the above example, in CH3CN/H2O is treated with excess trifluoroacetic acid. The solution is stirred several hours then purified by preparative reverse phase HPLC to afford 150 mg (65% yield) of the desired product. 1H NMR (CD3OD) δ 9.14–9.11 (d, J=8.7 Hz, 1H), 8.55–8.53 (d, J=5.4 Hz, 1H), 8.07–8.03 (m, 2H), 7.93–7.85 (m, 3H), 7.81–7.76 (m, 1H), 7.68–7.60 (m, 3H), 5.68 (bs, 1H), 5.49–5.43 (d, d, J=12.3, 3.9 Hz, 1H), 4.68–4.62 (m, 2H), 4.41–4.32 (m, 1H), 4.30–4.01 (m, 2H), 3.55–3.48 (m, 3H), 2.81–2.67 (m, 2H), 2.57–2.49 (d, d, d, J=16.2, 8.4, 1.2 Hz, 1H), 2.46–2.36 (d, d, J=15.0, 15.0 Hz, 1H); MS 608 (M+H).

Provenance & Evidence