Reaction Steps
1H NMR (CD3OD) δ 8.45 (s, 1H), 8.01–7.89 (m, 6H), 7.67–7.55 (m, 5H), 5.67 (bs, 1H), 5.43–5.38 (d, d, J=12.3, 3.9 Hz, 1H), 4.69–4.59 (m, 2H), 4.40–4.32 (m, 1H), 4.19 (s, 2H), 3.51 (s, 2H), 3.46–3.45 (d, J=3.6 Hz, 1H), 2.77–2.64 (m, 2H), 2.60–2.41 (m, 2H); MS 607 (M+H). Naphthalene-2-carboxylic acid {1-[(2-hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-6-[(4-methoxy-benzenesulfonylamino)-methyl}-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl}-amide: 1H NMR (CD3OD) δ 8.46 (s, 1H), 8.02–7.92 (m, 4H), 7.85–7.82 (d, J=8.7 Hz, 2H), 7.64–7.56 (m, 2H), 7.14–7.11 (d, J=9.3 Hz, 1H), 5.67 (bs, 1H), 5.41–5.35 (d, d, J=12.6, 4.2 Hz, 1H), 4.69–4.66 (d, d, J=4.8, 4.2 Hz, 1H), 4.62–4.58 (d, J=16.5 Hz, 1H), 4.40–4.31 (m, 1H), 4.25–4.13 (m, 2H), 3.96 (s, 3H), 3.53–3.33 (m, 3H), 2.77–2.64 (m, 2H), 2.57–2.49 (m, 2H); MS 637.4 (M+H). Naphthalene-2-carboxylic acid {1-[(2-hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-2-oxo-6-[(toluene-3-sulfonylamino)-methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl}-amide: 1H NMR (CD3OD) δ 8.46 (s, 1H), 8.02–7.91 (m, 4H), 7.72–7.68 (m, 2H), 7.62–7.56 (m, 2H), 7.51–7.49 (m, 2H), 5.67 (bs, 1H), 5.43–5.37 (d, d, J=12.9, 4.5 Hz, 1H), 4.69–4.66 (d, d, J=4.5, 3.9 Hz, 1H), 4.65–4.59 (d, J=16.8 Hz, 1H), 4.40–4.31 (m, 1H), 4.26–4.19 (d, J=16.5 Hz, 1H), 4.18–4.12 (d, J=16.5 Hz, 1H), 3.53–3.46 (m, 3H), 2.77–2.67 (m, 2H), 2.57–2.49 (m, 2H), 2.47 (s, 3H); MS 621.2 (M+H).
