化工社化工社 化学情報印刷レポート · 研究参考用
Methyl 2-methyl-6-nitrobenzoate → Benzoic acid, 2-amino-6-methyl-, methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 2-methyl-6-nitrobenzoate | HCID 596057 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Benzoic acid, 2-amino-6-methyl-, methyl ester | HCID 583916 | — |
反応手順
2-Methyl-6-nitrobenzoic acid is reacted with trimethylsilyldiazomethane to yield methyl 2-methyl-6-nitrobenzoate with m.p. 44–45° (Chem. Pharm. Bull., Vol. 29, 1475 (1981)). Methyl 2-methyl-6-nitrobenzoate is hydrogenated in methanol in the presence of palladium, 10% on carbon powder, at room temperature and atmospheric pressure to give methyl 2-methyl-6-aminobenzoate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07002022B2 |
| 出典データセット | uspto-grants-2006_02 |
| ORD ID | ord-b03d0cdcce9948cdb713843722b25123 |
| 出典メモ | uspto-grants-2006_02 |