2-benzyl-4,5-dibromopyridazin-3(2H)-one → 2-Benzyl-4-methoxy-5-bromo-3(2H)-pyridazinone

HRID 891332Notes

Reaction equation

HRID 891332 reaction equation
[CH2:1]([N:8]1[C:13](=[O:14])[C:12](Br)=[C:11]([Br:16])[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)CN1[C:25](=[O:26])C(Br)=C(Br)C=N1>CO>[CH2:1]([N:8]1[C:13](=[O:14])[C:12]([O:26][CH3:25])=[C:11]([Br:16])[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 99026992-benzyl-4,5-dibromopyridazin-3(2H)-oneHCID 160910464,5-Dibromo-2-(2,2,2-trifluoroethyl)-2,3-dihydropyridazin-3-one

Product 1

HCID 219339332-Benzyl-4-methoxy-5-bromo-3(2H)-pyridazinone

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Benzyl-4-methoxy-5-bromo-3(2H)-pyridazinone is prepared according to the method of Example 83B starting with 2-benzyl-4,5-dibromo-3(2H)-pyridazinone, in place of 2-(2,2,2-trifluoroethyl)-4,5-dibromo-3(2H)-pyridazinone and substituting methanol in place of isopropanol.

Sources & evidence

ORD record
ord-04c56ca79cbb4512bb700321fa49ef65
Source dataset
uspto-grants-2006_02
Patent number
US07001895B2

Reaction notes

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