2-Benzyl-4-methoxy-5-bromo-3(2H)-pyridazinone → 2-benzyl-4-methoxy-5-[3-fluoro-4-(methylthio)phenyl]-3(2H)-pyridazinone

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3-Fluoro-4-(methylthio)benzeneboronic acid and 2-benzyl-4-methoxy-5-bromo-3(2H)-pyridazinone were coupled according to the method of Example 83C to provide 2-benzyl-4-methoxy-5-[3-fluoro-4-(methylthio)phenyl]-3(2H)-pyridazinone as a yellow solid (yield: 4.98 g, 91%). 1H NMR (300 MHz, CDCl3) ? 7.76 (s, 1H), 7.47 (m, 2H), 7.39-7.21 (m, 7H), 5.34 (s, 2H), 4.13 (s, 3H), 2.51 (s, 3H). MS (DCI/NH3) m/z 357 (M+H)+, m/z 374 (M+NH4)+.

Provenance & Evidence