Ammonia → HCID 21934185, compound

HRID 891360Notes

Reaction equation

HRID 891360 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]2[C:10](=[O:25])[NH:11][N:12]=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:17][CH:16]=2)=[CH:4][CH:3]=1.I[C:27]1[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=1.N>>[F:33][C:30]1[CH:31]=[CH:32][C:27]([N:11]2[C:10](=[O:25])[C:9]([CH2:8][C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[C:14]([C:15]3[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:17][CH:16]=3)[CH:13]=[N:12]2)=[CH:28][CH:29]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 96054-FluoroiodobenzeneHCID 21933842HCID 21933842, compound

Product 1

HCID 21934185HCID 21934185, compound

Procedure

The title compound was prepared according to the method of Example 62, starting with 4-(4-fluorophenylmethyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone and reacting with 1-iodo-4-fluorobenzene (yield: 0.0881 g, 78%). mp 175-177° C. 1H NMR (300 MHz, DMSO d6) δ 3.27-3.36 (3H, obstructed by H2O), 3.88 (bs, 2H), 6.98-7.09 (m, 4H), 7.34 (m, 2H), 7.65 (m, 2H), 7.71 (m, 2H), 8.06 (m, 3H). MS (DCI/NH3) m/z 453 (M+H)+, 470 (M+NH4)+. Anal. calc. for C24H18F2N2O3S: C, 63.71; H, 4.01; N, 6.19. Found: C, 63.61; H, 4.26; N, 6.03.

Sources & evidence

ORD record
ord-7648c40fbe90400186d04f24e84650ce
Source dataset
uspto-grants-2006_02
Patent number
US07001895B2

Reaction notes

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