Ammonia → HCID 21933966, compound

HRID 891377Notes

Reaction equation

HRID 891377 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:9]2[C:14](=[O:15])[C:13]([O:16][C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)=[C:12]([C:24]3[CH:29]=[CH:28][C:27]([S:30](C)(=[O:32])=[O:31])=[C:26]([F:34])[CH:25]=3)[CH:11]=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8].[NH3:35]>>[F:1][C:2]1[CH:3]=[C:4]([N:9]2[C:14](=[O:15])[C:13]([O:16][C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)=[C:12]([C:24]3[CH:29]=[CH:28][C:27]([S:30]([NH2:35])(=[O:32])=[O:31])=[C:26]([F:34])[CH:25]=3)[CH:11]=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 21934037HCID 21934037, compound

Product 1

HCID 21933966HCID 21933966, compound

Procedure

The title compound was prepared according to the method of Example 384 substituting 2-(3,4-difluorophenyl)-4-(4-fluorophenoxy)-5-[3-fluoro-4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone in place of 2-benzyl-4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone (yield: 125 mg, 31%). mp 224-226° C. 1H NMR (300 MHz, DMSO-d6) δ 7.15 (d, 4H), 7.51 (m, 1H), 7.6 (m, 2H) 7.75 (m, 4H), 7.9 (t, 1H); 8.4 (s, 1H). MS (DCI/NH3) m/z 492 (M+H)+, 509 (M+NH4)+. Anal. calc. for C22H13F4N3O4S: C, 53.77; H, 2.67; N, 8.55. Found, C,; 53.33; H, 2.84; N, 8.22

Sources & evidence

ORD record
ord-a34e205b8bbd47cf8eea881e558c7c30
Source dataset
uspto-grants-2006_02
Patent number
US07001895B2

Reaction notes

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