HCID 178503118, compound → HCID 21933876, compound

HRID 891397Notes

Reaction equation

HRID 891397 reaction equation
[F:1][C:2]([F:21])([F:20])[CH2:3][N:4]1[C:9](=[O:10])[C:8]([OH:11])=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=2)[CH:6]=[N:5]1>CC(C)CCO>[F:21][C:2]([F:1])([F:20])[CH2:3][N:4]1[C:9](=[O:10])[C:8]([O:11][CH2:9][CH2:8][CH:7]([CH3:12])[CH3:6])=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=2)[CH:6]=[N:5]1

Participants

3

Reactant 1

HCID 178503118HCID 178503118, compound

Product 1

HCID 21933876HCID 21933876, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

The intermediate, 2-(2,2,2-trifluoroethyl)-4-hydroxy-5-[4-(methylthio)phenyl]-3(2H)-pyridazinone prepared in Example 90C was reacted with 3-methyl-1-butanol to provide 2-(2,2,2-trifluoroethyl)-4-(3-methylbutoxy)-5-[4-(methylthio)phenyl]-3(2H)-pyridazinone according to the method of Example 90D.

Sources & evidence

ORD record
ord-80930f5ffe1f4258a1bbdf1296570873
Source dataset
uspto-grants-2006_02
Patent number
US07001895B2

Reaction notes

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