Ammonia → HCID 10138015, compound

HRID 891402Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:9](=[O:24])[NH:10][N:11]=[CH:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([S:20]([CH3:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[CH:5]=[CH:6][CH:7]=1.N>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:10]2[C:9](=[O:24])[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=3)=[C:13]([C:14]3[CH:19]=[CH:18][C:17]([S:20]([CH3:23])(=[O:21])=[O:22])=[CH:16][CH:15]=3)[CH:12]=[N:11]2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 222Ammonia

HCID 21933908HCID 21933908, compound

Product 1

HCID 10138015HCID 10138015, compound

Procedure

The title compound was prepared as described in Example 62, substituting 4-(3-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone in place of 4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone (yield: 135 mg, 34%). mp 199-201° C. 1H NMR (300 MHz, DMSO-d6) δ 3.24 (s, 3H), 6.98 (d, J=9 Hz, 1H), 7.18 (m, 2H), 7.32 (m, 1H), 7.39 (t, 1H), 7.54 (d, J=9 Hz, 2H), 7.71 (m, 2H), 7.91 (d, J=9 Hz, 2H), 8.27 (s, 1H). MS (DCI/NH3) m/z 439 (M+H)+, 456 (M+NH4)+.

Sources & evidence

ORD record: ord-5ba9ac89c52a4f77b5b6e92a04ad48d0
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07001895B2

Reaction notes

Loading…