Ammonia → HCID 10226950, compound

Participants

Reaction Steps

The title compound was prepared according to the method of Example 459, substituting 2-(3-chloro-4-fluorophenyl)-4-(2-hydroxy-2-methyl-1-propoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone (Example 479) in place of 2-(3,4-difluorophenyl)-4-(2-hydroxy-2-methyl-1-propoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone. mp 176-178° C., 1H NMR (300 MHz, CDCl3) δ 1.00 (s, 6H), 4.19 (s, 2H), 4.54 (s, 1H), 7.49 (s, 2H), 7.62 (t, 1H, J=9 Hz), 7.66 (ddd, 1H, J=2,5,9 Hz), 7.92 (s, 4.5H), 7.94 (d, 0.5H, J=2 Hz), 8.20 (s, 1H); MS (DCI/NH3) m/z 468 (M+H)+; 1 Cl, 490 (M+Na)+;1 Cl; Anal. Calcd for C20H19ClFN2O5S: C, 51.34; H, 4.09; N, 8.98. Found: C, 51.33; H, 4.23; N, 8.76.

Provenance & Evidence