Tetrabutylammonium Fluoride → HCID 22242765, compound

Participants

Reaction Steps

To a solution of 3-t-butyldiphenylsilyloxy-1-(4-carbamoyl-1,3-oxazol-2-yl)azetidine (1.30 g, 3.08 mmol) in tetrahydrofuran (60 ml) was added a solution of 1.0M tetra-n-butylammonium fluoride in tetrahydrofuran (3.1 ml) in an ice bath, and the mixture was stirred for 1 hour. After checking the completion of the reaction, the reaction mixture was concentrated under reduced pressure. The residue was purified by chromatography on a silica gel column using ethyl acetate:methanol (10:1) as the eluant to afford 1-(4-carbamoyl-1,3-oxazol-2-yl)-3-hydroxyazetidine (0.43 g, yield 75%) as a white solid.

Provenance & Evidence