Tetrabutylammonium Fluoride → HCID 22242832, compound

Participants

Reaction Steps

To a solution of 3-t-butyldiphenylsilyloxy-1-(4-cyano-1,3-oxazol-2-yl)azetidine (0.61 g, 1.51 mmol) (obtained as described in Reference Example 23(1)) in tetrahydrofuran (30 ml) was added a solution of 1.0M tetra-n-butylammonium fluoride in tetrahydrofuran (1.5 ml) in an ice bath, and the mixture was stirred for 1 hour. After checking the completion of the reaction, the reaction mixture was concentrated under reduced pressure. The residue was purified by chromatography on a silica gel column using ethyl acetate as the eluant to afford 1-(4-cyano-1,3-oxazol-2-yl)-3-hydroxyazetidine (0.21 g, yield 86%) as a white solid.

Provenance & Evidence