Tetrabutylammonium Fluoride → HCID 22242789, compound

Participants

Reaction Steps

To a solution of 3-t-butyldiphenylsilyloxy-1-(4-thiomorpholinocarbonyl-1,3-thiazol-2-yl)azetidine (1.16 g, 2.10 mmol) (obtained as described in Reference Example 25(1)) in anhydrous tetrahydrofuran (35 ml) was added a solution of 1.0M tetra-n-butylammonium fluoride in tetrahydrofuran (2.52 ml, 2.52 mmol), and the reaction mixture was stirred for 30 minutes. After checking the completion of the reaction, the reaction mixture was concentrated under reduced pressure, and the residue was purified by chromatography on a silica gel column using ethyl acetate as the eluant to afford 1-(4-thiomorpholinocarbonyl-1,3-thiazol-2-yl)-3-hydroxyazetidine (599 mg, yield 100%) as a white solid.

Provenance & Evidence