Hydrochloric Acid → Sarcosine p-nitrobenzyl ester hydrochloride

Participants

Reaction Steps

To a solution of (N-t-butoxycarbonyl-N-methyl-amino)acetic acid p-nitrobenzyl ester (4.30 g, 133 mmol) (obtained as described in Reference Example 43(1)) was added a solution of 4N hydrogen chloride in 1,4-dioxane (4.3 ml) in an ice bath, and the mixture was stirred at room temperature for 2.5 hours. After checking the completion of the reaction, diethyl ether was added thereto and the reaction mixture was stirred for 30 minutes. The resulting reaction mixture was filtered and the obtained residue was washed with diethyl ether and dried to give sarcosine p-nitrobenzyl ester hydrochloride (3.04 g, yield 88%).

Provenance & Evidence