HCID 61600402, compound → N-Boc-N-isopropylamino-acetic acid

Participants

Reaction Steps

To a solution of (N-t-butoxycarbonyl-N-isopropyl-amino)-acetic acid methyl ester (5.59 g, 24.2 mmol) in a mixture of methanol (112 ml) and distilled water (56 ml) was added 1M aqueous sodium hydroxide solution (37 ml) in an ice bath, and the mixture was stirred at room temperature for 7 hours. After checking the completion of the reaction, Dowex-50W was added thereto in the ice bath to adjust the pH of the reaction mixture to 5 to 4. The reaction mixture was filtered and the filtrate concentrated under reduced pressure to give (N-t-butoxycarbonyl-N-isopropyl-amino)acetic acid (5.25 g) as a crude product.

Provenance & Evidence