3-(Tributylstannyl)pyridine → HCID 9998304, compound

Participants

Reaction Conditions

Reaction Steps

7-(3-Bromo-4-methylphenyl)-3-trifluoromethylimidazo[1,2-b][1,2,4]triazine (28 mg, 78 μmol) was dissolved in tetrahydrofuran (3 ml) under nitrogen and degassed for 10 min before 3-(tributylstannyl)pyridine (37 mg, 100 μmol) and tetrakis(triphenylphosphine)palladium(0) (10 mg, 9 μmol) were added. The stirred mixture was heated at 80° C. for 48 h. Solvent was removed in vacuo and the residue purified by chromatography (silica gel, 50% EtOAc/isohexane) to give 12 mg of the title compound as a yellow solid: 1H NMR (400 MHz, CDCl3) δ 2.37 (3H, s), 7.40–7.44 (1H, m), 7.50 (1H, d, J 8.2), 7.71–7.75 (1H, m), 7.98 (1H, d, J 1.9), 8.03 (1H, dd, J 1.9, 8.0), 8.62 (1H, s), 8.65–8.68 (2H, m), 8.79 (1H, s); MS (ES+) m/z 356 [M+H]+.

Provenance & Evidence