Sodium Hydroxide → HCID 22240238, compound

HRID 891871Notes

Reaction equation

HRID 891871 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)[N:6]=[N:7][CH:8]=1.[OH-].[Na+]>O1CCOCC1>[N:10]1([CH2:9][C:5]2[NH:6][N:7]=[CH:8][C:3](=[O:2])[CH:4]=2)[CH:14]=[CH:13][N:12]=[CH:11]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22240182HCID 22240182, compound

Product 1

HCID 22240238HCID 22240238, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The 5-methoxy-3-(imidazol-1-yl-methyl)-pyridazine (IX) is dissolved in dioxane and NaOH is added. The mixture is refluxed for about 7 hours, cooled to room temperature and quenched with HCl. The pH is adjusted to 8 with saturated solution of NaHCO3. The solvent is removed in vacuo and the residue is taken in MeOH. After filtration, the solvent is removed in vacuo and diluted with MeOH to provide the corresponding 6-(imidazol-1-yl-methyl)-1H-pyridazin-4-one (X).

Workup

  1. temperatureThe mixture is refluxed for about 7 hours
  2. customquenched with HCl
  3. customThe solvent is removed in vacuo
  4. filtrationAfter filtration
  5. customthe solvent is removed in vacuo
  6. additiondiluted with MeOH

Sources & evidence

ORD record
ord-2971610eb77640d3945d3daa9f233947
Source dataset
uspto-grants-2006_02
Patent number
US07005432B2

Reaction notes

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