Phosphorus oxychloride → HCID 22240145, compound

Participants

Reaction Conditions

Reaction Steps

6-(imidazol-1-yl-methyl)-1H-pyridazin-4-one (X) is taken in phosphorus oxychloride under argon. The mixture is stirred in a 60° C. oilbath for 1.5 hour. The solvent is removed in vacuo and the residue is dissolved in water under icebath cooling. The solution is neutralized with solid NaHCO3 and the aqueous layer is extracted with MeCl2 to provide the corresponding 5-chloro-3-(imidazol-1-yl-methyl)-pyridazine (IV A).

Provenance & Evidence