HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 891873Generated: November 1, 2026
Cesium carbonate → HCID 22240163, compound
https://huagongshe.com/reaction/891873
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| Reactant | 3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) | HCID 2734660 | — |
| Reactant | 3-Chloro-5-methoxypyridazine | HCID 10975612 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 22240163 | HCID 22240163 | — |
Reaction Steps
3-Chloro-5-methoxy-pyridazine (Bryant, R. D.; Kunng, F.-A.; South, M. S. J. Heterocycl. Chem. (1995), 32(5), 1473-6.), 3-chloro-4-fluorophenylboronic acid, Cs2CO3 and tris(dibenzylideneacetone)dipalladium chloroform complex are mixed and a solution of tri-tert-butylphosphine in degassed dioxane is added. The mixture is heated at about 90° C. for 22 hours then cooled to room temperature, ethylacetate is added, the solid is filtered and the filtrate is concentrated in vacuo to provide 3-(3-chloro-4-fluoro-phenyl)-5-methoxy-pyridazine (a compound of formula XI).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07005432B2 |
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| Source dataset | uspto-grants-2006_02 |
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| ORD ID | ord-42be0ef4d16a42f093d639596df46db4 |
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| Source note | uspto-grants-2006_02 |
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