Potassium Carbonate → HCID 22240218, compound

Participants

Reaction Steps

5-Chloro-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine (0.07 g, 0.34 mmol), 3-chloro-4-fluorophenylboronic acid (0.076 g, 0.44 mmol), K2CO3 (0.09 g, 0.67 mmol) and tetrakis(triphenylphosphine)palladium (0.04 g, 0.034 mmol) were mixed and degassed dioxane (1.4 ml) was added. The mixture was refluxed for 44 hours and the solvent was removed in vacuo. The residue was taken in MeCl2, filtrated and the filtrate was concentrated in vacuo. The residue was chromatographed over silica gel (CH2Cl2—MeOH 98:02) to provide a white foam which was dissolved in MeOH (2 ml). HCl-Et2O was added to provide 5-(3-chloro-4-fluoro-phenyl)-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine hydrochloride (0.1 g, 77%) as an offwhite solid, MS: m/e=302.7 (M+).

Provenance & Evidence