5-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine → HCID 22240310, compound

HRID 891876Notes

Reaction equation

HRID 891876 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](B2OC(C)(C)C(C)(C)O2)=[CH:4][C:3]=1[C:17]([F:20])([F:19])[F:18].[Cl:21][C:22]1[CH:23]=[C:24]([CH2:28][N:29]2[CH:33]=[CH:32][N:31]=[C:30]2[CH3:34])[N:25]=[N:26][CH:27]=1>>[ClH:21].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:22]2[CH:23]=[C:24]([CH2:28][N:29]3[CH:33]=[CH:32][N:31]=[C:30]3[CH3:34])[N:25]=[N:26][CH:27]=2)=[CH:4][C:3]=1[C:17]([F:18])([F:19])[F:20]

Participants

3

Reactant 2

HCID 117890255-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazineHCID 222401762-[4-Fluoro-3-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product 1

HCID 22240310HCID 22240310, compound

Procedure

The title compound, MS: m/e=337.2 (M+H+), was prepared from 2-(4-fluoro-3-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane and 5-chloro-3-(2-methyl-imidazol-1-ylmethyl)-pyridazine.

Sources & evidence

ORD record
ord-0391357481b84438b17bdd2b8e43799a
Source dataset
uspto-grants-2006_02
Patent number
US07005432B2

Reaction notes

Loading…