2-(1-Benzothiophen-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → 5-Benzo[b]thiophen-5-yl-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine Hydrochloride

HRID 891886Notes

Reaction equation

HRID 891886 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[C:7](B3OC(C)(C)C(C)(C)O3)[CH:8]=[CH:9][C:2]1=2.[Cl:19][C:20]1[CH:21]=[C:22]([CH2:26][N:27]2[CH:31]=[CH:30][N:29]=[C:28]2[CH3:32])[N:23]=[N:24][CH:25]=1>>[ClH:19].[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[C:7]([C:20]3[CH:21]=[C:22]([CH2:26][N:27]4[CH:31]=[CH:30][N:29]=[C:28]4[CH3:32])[N:23]=[N:24][CH:25]=3)[CH:8]=[CH:9][C:2]1=2

Participants

3

Reactant 2

HCID 27954552-(1-Benzothiophen-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 117890255-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine

Product 1

HCID 222401325-Benzo[b]thiophen-5-yl-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine Hydrochloride

Procedure

The title compound, MS: m/e=307.3 (M+H+), was prepared from 2-benzo[b]thiophen-5-yl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane and 5-chloro-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine.

Sources & evidence

ORD record
ord-f77b98f1bd484182907e20221892947a
Source dataset
uspto-grants-2006_02
Patent number
US07005432B2

Reaction notes

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