2-(4-Chloro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → 5-(4-Chloro-3-methyl-phenyl)-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine Hydrochloride

HRID 891901Notes

Reaction equation

HRID 891901 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](B2OC(C)(C)C(C)(C)O2)=[CH:4][C:3]=1[CH3:17].Cl[C:19]1[CH:20]=[C:21]([CH2:25][N:26]2[CH:30]=[CH:29][N:28]=[C:27]2[CH3:31])[N:22]=[N:23][CH:24]=1>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:19]2[CH:20]=[C:21]([CH2:25][N:26]3[CH:30]=[CH:29][N:28]=[C:27]3[CH3:31])[N:22]=[N:23][CH:24]=2)=[CH:4][C:3]=1[CH3:17]

Participants

3

Reactant 2

HCID 37676412-(4-Chloro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 117890255-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine

Product 1

HCID 222401735-(4-Chloro-3-methyl-phenyl)-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine Hydrochloride

Procedure

The title compound, MS: m/e=299.3 (M+H+), was prepared from 2-(4-chloro-3-methyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane and 5-chloro-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine.

Sources & evidence

ORD record
ord-17747b1f6ba247d3853f9c34499b101e
Source dataset
uspto-grants-2006_02
Patent number
US07005432B2

Reaction notes

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