5-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine → HCID 22240228, compound

HRID 891903Notes

Reaction equation

HRID 891903 reaction equation
[F:1][CH:2]([F:17])[C:3]1[S:7][CH:6]=[C:5](B2OC(C)(C)C(C)(C)O2)[CH:4]=1.[Cl:18][C:19]1[CH:20]=[C:21]([CH2:25][N:26]2[CH:30]=[CH:29][N:28]=[C:27]2[CH3:31])[N:22]=[N:23][CH:24]=1>>[ClH:18].[F:17][CH:2]([F:1])[C:3]1[S:7][CH:6]=[C:5]([C:19]2[CH:20]=[C:21]([CH2:25][N:26]3[CH:30]=[CH:29][N:28]=[C:27]3[CH3:31])[N:22]=[N:23][CH:24]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 117890255-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazineHCID 22240122HCID 22240122, compound

Product 1

HCID 22240228HCID 22240228, compound

Procedure

The title compound, MS: m/e=307.2 (M+H+), was prepared from 2-(5-difluoromethyl-thiophen-3-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane and 5-chloro-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine.

Sources & evidence

ORD record
ord-caa71bb342cf4c24895980becfe60540
Source dataset
uspto-grants-2006_02
Patent number
US07005432B2

Reaction notes

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