5-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine → HCID 22240306, compound

HRID 891910Notes

Reaction equation

HRID 891910 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](B2OC(C)(C)C(C)(C)O2)=[CH:4][C:3]=1[C:17]([F:20])([F:19])[CH3:18].Cl[C:22]1[CH:23]=[C:24]([CH2:28][N:29]2[CH:33]=[CH:32][N:31]=[C:30]2[CH3:34])[N:25]=[N:26][CH:27]=1>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:22]2[CH:23]=[C:24]([CH2:28][N:29]3[CH:33]=[CH:32][N:31]=[C:30]3[CH3:34])[N:25]=[N:26][CH:27]=2)=[CH:4][C:3]=1[C:17]([F:19])([F:20])[CH3:18]

Participants

3

Reactant 2

HCID 117890255-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazineHCID 22240136HCID 22240136, compound

Product 1

HCID 22240306HCID 22240306, compound

Procedure

The title compound, MS: m/e=349.4 (M+H+), was prepared from 2-[4-chloro-3-(1,1-difluoro-ethyl)-phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane and 5-chloro-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine.

Sources & evidence

ORD record
ord-32189dfc9721493fba3eff7ea8b82b7a
Source dataset
uspto-grants-2006_02
Patent number
US07005432B2

Reaction notes

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