5-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine → 5-(7-Ethoxy-naphthalen-2-yl)-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine Hydrochloride

HRID 891914Notes

Reaction equation

HRID 891914 reaction equation
[CH2:1]([O:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][C:10](B3OC(C)(C)C(C)(C)O3)=[CH:11]2)=[CH:6][CH:5]=1)[CH3:2].[Cl:23][C:24]1[CH:25]=[C:26]([CH2:30][N:31]2[CH:35]=[CH:34][N:33]=[C:32]2[CH3:36])[N:27]=[N:28][CH:29]=1>>[ClH:23].[CH2:1]([O:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][C:10]([C:24]3[CH:25]=[C:26]([CH2:30][N:31]4[CH:35]=[CH:34][N:33]=[C:32]4[CH3:36])[N:27]=[N:28][CH:29]=3)=[CH:11]2)=[CH:6][CH:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 117890255-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazineHCID 222402002-(7-Ethoxynaphthalen-2-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Product 1

HCID 222402335-(7-Ethoxy-naphthalen-2-yl)-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine Hydrochloride

Procedure

The title compound, MS: m/e=345.4 (M+H+), was prepared from 2-(7-ethoxy-naphthalen-2-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane and 5-chloro-3-(2-methyl-imidazol-1-ylmethyl)-pyridazine.

Sources & evidence

ORD record
ord-a458a15efd6a42379c3e18bef304b76a
Source dataset
uspto-grants-2006_02
Patent number
US07005432B2

Reaction notes

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