5-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine → 5-(6-Methoxy-naphthalen-1-yl)-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine

HRID 891924Notes

Reaction equation

HRID 891924 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](B1OC(C)(C)C(C)(C)O1)=[CH:8][CH:7]=[CH:6]2.Cl[C:23]1[CH:24]=[C:25]([CH2:29][N:30]2[CH:34]=[CH:33][N:32]=[C:31]2[CH3:35])[N:26]=[N:27][CH:28]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9]([C:23]1[CH:24]=[C:25]([CH2:29][N:30]3[CH:34]=[CH:33][N:32]=[C:31]3[CH3:35])[N:26]=[N:27][CH:28]=1)=[CH:8][CH:7]=[CH:6]2

Participants

3

Reactant 2

HCID 117890255-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazineHCID 222402302-(6-Methoxynaphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product 1

HCID 222402735-(6-Methoxy-naphthalen-1-yl)-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine

Procedure

The title compound, MS: m/e=331.4 (M+H+), was prepared from 2-(6-methoxy-naphthalen-1-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane and 5-chloro-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine.

Sources & evidence

ORD record
ord-9d54ec7e324c4056b1d3fef7d0214c2c
Source dataset
uspto-grants-2006_02
Patent number
US07005432B2

Reaction notes

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