5-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine → 5-(5-Methoxy-naphthalen-2-yl)-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine

HRID 891926Notes

Reaction equation

HRID 891926 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[CH:6][C:7](B1OC(C)(C)C(C)(C)O1)=[CH:8]2.Cl[C:23]1[CH:24]=[C:25]([CH2:29][N:30]2[CH:34]=[CH:33][N:32]=[C:31]2[CH3:35])[N:26]=[N:27][CH:28]=1>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[CH:6][C:7]([C:23]1[CH:24]=[C:25]([CH2:29][N:30]3[CH:34]=[CH:33][N:32]=[C:31]3[CH3:35])[N:26]=[N:27][CH:28]=1)=[CH:8]2

Participants

3

Reactant 2

HCID 117890255-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazineHCID 222402962-(5-Methoxynaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product 1

HCID 222401555-(5-Methoxy-naphthalen-2-yl)-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine

Procedure

The title compound, MS: m/e 331.4 (M+H+), was prepared from 2-(5-methoxy-naphthalen-2-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane and 5-chloro-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine.

Sources & evidence

ORD record
ord-fde0eb67074243a5990685eb0c03366f
Source dataset
uspto-grants-2006_02
Patent number
US07005432B2

Reaction notes

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