4-FLUORO-3-CYCLOPROPYLPHENYLBORONIC ACID PINACOL ESTER → HCID 10018138, compound

HRID 891932Notes

Reaction equation

HRID 891932 reaction equation
[CH:1]1([C:4]2[CH:5]=[C:6](B3OC(C)(C)C(C)(C)O3)[CH:7]=[CH:8][C:9]=2[F:10])[CH2:3][CH2:2]1.Cl[C:21]1[CH:22]=[C:23]([CH2:27][N:28]2[CH:32]=[CH:31][N:30]=[C:29]2[CH3:33])[N:24]=[N:25][CH:26]=1>>[CH:1]1([C:4]2[CH:5]=[C:6]([C:21]3[CH:22]=[C:23]([CH2:27][N:28]4[CH:32]=[CH:31][N:30]=[C:29]4[CH3:33])[N:24]=[N:25][CH:26]=3)[CH:7]=[CH:8][C:9]=2[F:10])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 112307744-FLUORO-3-CYCLOPROPYLPHENYLBORONIC ACID PINACOL ESTERHCID 117890255-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine

Product 1

HCID 10018138HCID 10018138, compound

Procedure

The title compound, MS: m/e=309.4 (M+H30), was prepared from 2-(3-cyclopropyl-4-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane and 5-chloro-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine.

Sources & evidence

ORD record
ord-4fdebba6321442b6bbd928a1a9bf6464
Source dataset
uspto-grants-2006_02
Patent number
US07005432B2

Reaction notes

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