Hydrazine → HCID 178424851, compound

HRID 892048Notes

Reaction equation

HRID 892048 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH2:10][C:11]#[N:12])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[NH2:14][NH2:15]>CCO>[CH3:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([NH2:12])[NH:14][N:15]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 142219003-(3,5-Dimethylphenyl)-3-oxopropanenitrile

Product 1

HCID 178424851HCID 178424851, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-(3,5-Dimethyl-phenyl)-3-oxo-propionitrile (2.0175 gms.) is then suspended in 55 mL of anhydrous EtOH. This suspension is treated with 0.73 mL of anhydrous hydrazine and subsequently heated to refluxing temperature for 1 day. The reaction mixture is concentrated in vacuo. The residue is then triturated with isopropanol to precipitate out the 5-(3,5-dimethyl-phenyl)-2H-pyrazol-3-ylamine as a white solid.

Workup

  1. temperaturesubsequently heated
  2. temperatureto refluxing temperature for 1 day
  3. concentrationThe reaction mixture is concentrated in vacuo
  4. customThe residue is then triturated with isopropanol
  5. customto precipitate out the 5-(3,5-dimethyl-phenyl)-2H-pyrazol-3-ylamine as a white solid

Sources & evidence

ORD record
ord-d0d150858859474cb939e33b91fd7b93
Source dataset
uspto-grants-2006_02
Patent number
US07005444B2

Reaction notes

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