Hydrazine → HCID 178489313, compound

HRID 892062Notes

Reaction equation

HRID 892062 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9](=O)[CH2:10][C:11]#[N:12].[NH2:14][NH2:15]>CCO>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[C:11]([NH2:12])[NH:14][N:15]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 49627502-Methoxybenzoylacetonitrile

Product 1

HCID 178489313HCID 178489313, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-(2-Methoxy-phenyl)-3-oxo-propionitrile (2.4954 gms.) is then suspended in 55 mL of anhydrous EtOH. This suspension is treated with 0.90 mL of anhydrous hydrazine and subsequently heated to refluxing temperature for 1 day. The reaction mixture is concentrated in vacuo. The residue is then triturated with isopropanol to precipitate out the 5-(2-methoxy-phenyl)-2H-pyrazol-3-ylamine.

Workup

  1. temperaturesubsequently heated
  2. temperatureto refluxing temperature for 1 day
  3. concentrationThe reaction mixture is concentrated in vacuo
  4. customThe residue is then triturated with isopropanol
  5. customto precipitate out the 5-(2-methoxy-phenyl)-2H-pyrazol-3-ylamine

Sources & evidence

ORD record
ord-b0b2ed397f6747758f6638cd1ce2c7ca
Source dataset
uspto-grants-2006_02
Patent number
US07005444B2

Reaction notes

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