反应详情

3-Oxo-4-m-tolyl-butyronitrile (2.5583 gms.) is then suspended in 50 mL of anhydrous EtOH. This suspension is treated with 1.0 mL of anhydrous hydrazine, and subsequently heated to refluxing temperature for 1 day. The reaction mixture is concentrated in vacuo. The residue is then triturated with isopropanol to precipitate out the 5-(3-methyl-benzyl)-2H-pyrazol-3-ylamine.

1. temperaturesubsequently heated
2. temperatureto refluxing temperature for 1 day
3. concentrationThe reaction mixture is concentrated in vacuo
4. customThe residue is then triturated with isopropanol
5. customto precipitate out the 5-(3-methyl-benzyl)-2H-pyrazol-3-ylamine