HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 178418806, compound → 3-[[[5-[[4-[3-(dimethylamino)propoxy]phenyl]methyl]-1H-pyrazol-3-yl]amino]methylidene]-1H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 178418806 | HCID 178418806 | — |
| Reactant | HCID 178483571 | HCID 178483571 | — |
| Reactant | HCID 178517101 | HCID 178517101 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-[[[5-[[4-[3-(dimethylamino)propoxy]phenyl]methyl]-1H-pyrazol-3-yl]amino]methylidene]-1H-indol-2-one | HCID 178483570 | — |
Reaction Steps
The named compound is prepared by substituting 5-[4-(3-dimethylamino-propoxy)-benzyl]-2H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.0351 gms.) is reacted with 0.0881 gms. of 5-[4-(3-dimethylamino-propoxy)-benzyl]-2H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (2.0 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07005444B2 |
| Source dataset | uspto-grants-2006_02 |
| ORD ID | ord-dd533fe7ed8d41f3b3ba19bc7adf16cc |
| Source note | uspto-grants-2006_02 |