HCID 178418806, compound → 3-[[[5-[[4-(3-morpholin-4-ylpropoxy)phenyl]methyl]-1H-pyrazol-3-yl]amino]methylidene]-1H-indol-2-one

Participants

Reaction Steps

The named compound is prepared by substituting 5-[4-(3-morpholin-4-yl-propoxy)-benzyl]-2H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.017 gms.) is reacted with 0.048 gms. of 5-[4-(3-morpholin-4-yl-propoxy)-benzyl]-2H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (1.0 mL). Recrystallization from a mixture of ethyl acetate and hexanes affords the named compound.

Provenance & Evidence