HCID 69661640, compound → HCID 28804549, compound

Participants

Reaction Steps

To Compound A2 (550 mg, 2.15 mmol) obtained in Reference Example 2 was added concentrated hydrochloric acid (10 mL), and the mixture was stirred with heating for 7 hours. After the reaction mixture was cooled and the deposited solid was removed by filtration, the filtrate was concentrated under reduced pressure. The resulting oil was dissolved in methanol (20 mL) and water (1 mL), and to the solution was added BioRad AG-X8 (hydroxide form) until the solution became alkaline. After the resin was removed by filtration, the filtrate was concentrated under reduced pressure to obtain the title compound (310 mg, 95%).

Provenance & Evidence