HCID 22240025, compound → HCID 22240064, compound

Participants

Reaction Conditions

Reaction Steps

Compound 18 (500 mg, 0.98 mmol) obtained in Example 18 was dissolved in N,N-dimethylformamide (10 mL), to the solution was added phthalimide potassium salt (485 mg, 2.62 mmol, 2.7 equivalents), and the mixture was stirred at 120° C. for 4 hours. The reaction mixture was partitioned with ethyl acetate and water, and the organic layer was washed with saturated aqueous sodium hydrogen carbonate and dried over anhydrous magnesium sulfate. After the reaction mixture was concentrated, the residue was crystallized from dichloromethane and diethyl ether to obtain the title compound (500 mg, 78%) as white crystals.

Provenance & Evidence