Dimethylamine → HCID 178456586, compound

Participants

Reaction Conditions

Reaction Steps

Compound 42 (60 mg, 0.134 mmol) obtained in Example 42 was dissolved in tetrahydrofuran (3 mL), to the solution was added a 2 mol/L solution of dimethylamine (200 μL, 0.401 mmol, 3.1 equivalents) in tetrahydrofuran, and the mixture was stirred with heating at 70° C. for 5.5 hours. The reaction solution was concentrated and then directly purified by silica gel column chromatography (chloroform:methanol=99:1 to 97:3), and the title compound (7 mg, 19%) was obtained in a manner similar to the method by which Compound 40 was obtained from Adduct 40a in Example 40.

Provenance & Evidence