Diethyl Ether → HCID 69662130, compound

Participants

Reaction Steps

Compound 47 (100 mg, 0.218 mmol) obtained in Example 47 was dissolved in tetrahydrofuran (5 mL), to the solution was added a 3.0 mol/L solution (500 μL) of methyl magnesium bromide (1.50 mmol, 6.8 equivalents) in diethyl ether, and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated under reduced pressure and then the residue was directly purified by silica gel column chromatography (chloroform:methanol=95:5) to obtain the title compound (60 mg, 60%).

Provenance & Evidence