Sodium ethoxide → HCID 178467392, compound

Participants

Reaction Conditions

Reaction Steps

In a manner similar to that in Example 66, a cyclized compound was obtained from Compound C8 prepared in Reference Example 43, to a solution of the cyclized compound (4.88 g, 14.3 mmol) in ethanol (30 mL) was added a 21% solution of sodium ethoxide (30 mL, 93.0 mmol, 6.5 equivalents) in ethanol, and then the mixture was stirred with heating at 70° C. for 3 hours. The reaction solution was concentrated, and the deposited crystals were collected by filtration and recrystallized from ethyl acetate to obtain the title compound (2.67 g, 54%) as white crystals.

Provenance & Evidence