Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | (8R)-8-benzyl-5-chloro-2-cyclopentyl-7,8-dihydro-1H-imidazo[2,1-f]purine | HCID 178478320 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178510560 | HCID 178510560 | 73% |
Reaction Steps
Compound 67a (217 mg, 0.529 mmol) obtained in Example 67 was dissolved in N,N-dimethylformamide (4 mL), to the solution were added cesium carbonate (245 mg, 0.750 mmol, 1.5 equivalents) and potassium cyanide (39 mg, 0.600 mmol, 1.2 equivalents), and the mixture was stirred at 100° C. for 4 hours. To the reaction mixture was added water, and the deposited crystals were collected by filtration to obtain the title compound (125 mg, 73%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07005430B2 |
|---|
| Source dataset | uspto-grants-2006_02 |
|---|
| ORD ID | ord-5c95402e114d4d7c895781214309889d |
|---|
| Source note | uspto-grants-2006_02 |
|---|
