Aluminium lithium hydride → HCID 22241308, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled (0° C.) solution of 3-[(2-methoxyethoxy)-methoxy]-benzonitrile (3.9 g, 18.8 mmol, example 8) in THF (40 mL) is added LAH (40 mL, 1M in THF). The resulting solution is stirred for 10 min. then the cold bath removed and stirring continued for 2 h. The resulting mixture is cooled to 0° C. then water (1.5 mL) added dropwise followed by NaOH solution (1.5 mL, SM) and water (1.5 mL). The resulting suspension is diluted with ether then filtered through celite. The filtrate is concentrated to give the title compound which is used without further purification. MS (ESI) 211 (M+H)+.

Provenance & Evidence