2-Chlorobenzoxazole → 3-[(N-Benzoxazol-2-yl-N-methyl-amino)-methyl]-phenol

HRID 892140Notes

Reaction equation

HRID 892140 reaction equation
[CH3:1][NH:2][CH2:3][C:4]1[CH:5]=[C:6]([O:10]COCCOC)[CH:7]=[CH:8][CH:9]=1.Cl[C:18]1[O:19][C:20]2[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=2[N:22]=1>>[O:19]1[C:20]2[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=2[N:22]=[C:18]1[N:2]([CH2:3][C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)[CH3:1]

Participants

3

Reactant 2

HCID 119862-ChlorobenzoxazoleHCID 22241370HCID 22241370, compound

Product 1

HCID 222415023-[(N-Benzoxazol-2-yl-N-methyl-amino)-methyl]-phenol

Conditions

Temperature
140 °C

Procedure

MS (ESI) 255 (M+H)+. Prepared from 3-[(methylamino)-methyl]-(2-methoxyethoxy-methoxy)benzene (example 28) and 2-chloro-benzoxazole. Also, omit heating to 140° C. Reaction stirred at room temperature.

Workup

  1. customReaction

Sources & evidence

ORD record
ord-150ea36e1e3747918b0cb8d38eb9f14a
Source dataset
uspto-grants-2006_02
Patent number
US07005440B1

Reaction notes

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