HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzamide → Methyl (5-methyl-2-phenyl-1,3-oxazol-4-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzamide | HCID 2331 | — |
| Reactant | Methyl 4-bromo-3-oxopentanoate | HCID 9815681 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl (5-methyl-2-phenyl-1,3-oxazol-4-yl)acetate | HCID 2775318 | — |
Reaction Steps
A solution of benzamide (0.606 g, 5.00 mmoles) and methyl 4-bromo-3-oxopentanoate (1.05 g, 5.00 mmoles, example 31) are heated in toluene (6 ml) to 120° C. for 18 hours. The reaction is then purified by column chromatography (silica, 4:1 hex: EtOAc) to give the title compound as a clear oil. MS (APcI) 232 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07005440B1 |
| Source dataset | uspto-grants-2006_02 |
| ORD ID | ord-acb2b5cc517b41909ae213ef9a219990 |
| Source note | uspto-grants-2006_02 |