反应详情

Thionyl chloride (0.95 mL, 13 mmol) is added to a solution of [3-(quinolin-2-ylmethoxy)-phenyl]-methanol (2.9 g, 11 mmol, example 48) in dichloromethane (30 mL) and allowed to stir 18 h. The reaction is concentrated in vacuo and azeotroped twice from chloroform to yield the title compound which is used without further purification.

1. concentrationThe reaction is concentrated in vacuo
2. customazeotroped twice from chloroform